A Nero Wolfe Mystery (a.k.a. Nero Wolfe, The Nero Wolfe Mysteries) is a television series based on Rex Stout's classic series of detective stories that aired for two seasons (2001–2002) on the A&E Network. A stylized period drama set in New York City in the early 1950s, A Nero Wolfe Mystery was one of the Top 10 Basic Cable Dramas for 2002.

A Nero Wolfe Mystery creates the world of the brownstone on Manhattan's West 35th Street through high production values and a jazzy score by Michael Small. The language and spirit of the Stout originals are preserved in the teleplays, most of them written by consulting producer Sharon Elizabeth Doyle and the team of Lee Goldberg and William Rabkin (whose "Prisoner's Base" was nominated for an Edgar Award by the Mystery Writers of America).

The series was preceded by the original film The Golden Spiders: A Nero Wolfe Mystery, a Jaffe/Braunstein Films production that aired on A&E TV in March 2000. Veteran screenwriter Paul Monash adapted Rex Stout's 1953 novel, and Bill Duke directed. After the high ratings (3.2 million households) garnered by The Golden Spiders, A&E considered a series of two-hour Nero Wolfe films before ordering a weekly one-hour drama series into production.

In part 1 of "Prisoner's Base," Archie's paycheck reveals his weekly salary ($200) and Wolfe's address (914 West 35th Street).

In the tradition of a repertory theater company, each episode featured predominantly the same ensemble of guest actors, cast as different characters in each episode/story.