Deep Blue Sea is a 1999 science fiction action horror film that stars Thomas Jane, Samuel L. Jackson, and Saffron Burrows. The film was directed by Renny Harlin and was released in the United States on July 28, 1999.

The Deep Blue Sea (1955) is a film, directed by Anatole Litvak, starring Vivien Leigh and Kenneth More, and released by Twentieth Century Fox.

Samual L Jackson plays a businessman who sinks $200 million into a special project to help fight brain cancer. As part of this project, medical biologist Susan McAlester (Saffron Burrows) rather naughtily figures out a way to genetically embiggen shark brains, so that cancer-battling enzymes can be harvested. However, the shark subjects become super smart and decide they don't much like being cooped up in pens and being stabbed with hypodermics, so they figure a way to break out and make for the open sea... Written by John Smith

Aquatica is a research lab located in the ocean. Doctor Susan McAlester and Doctor Jim Whitlock are currently doing research to help in the re-activation of dormant human brain cells like those found in Alzheimer's Disease patients. It seems that sharks do not lose any brain activity as they age, leading Susan and Jim to think that the proteins found in the sharks' brains may lead to a cure for Alzheimer's Disease, which is what killed Susan's father. The research is being funded by a group of investors headed by Russell Franklin, and the investors are getting impatient with the pace of the research. It doesn't help that a shark got loose from Aquatica, and attacked a few teenagers who were on a pleasure romp. In an effort to save her project, Susan gets a forty-eight-hour reprieve from Russell, who goes to the Aquatica to see how his money is being spent. Susan skips a few steps in the research project and genetically re-engineers the DNA of three mako sharks in order to create larger makos so the makos will have larger brains. With only her weekend skeleton crew on board -- that is, marine biologist Janice Higgins, engineer Tom Scoggins, shark expert Carter Blake, meteorologist Brenda Kerns, and Aquatica chef Sherman "Preacher" Dudley -- Susan prepares for her experiment. The test is successful, but then they all see what Susan's genetic re-engineering on the sharks has done -- one of the sharks wakes up from an anesthetic and kills Jim. Susan and her crew radio for help, and a rescue helicopter crashes into the station during a tropical storm, and then another shark attack leaves Aquatica sinking into the water. The surviving crew members do whatever they can think of to escape from Aquatica while they're trying to fight off the three sharks. Written by Todd Baldridge

Dr. Susan McAlester is trying to cure Alzheimer's. But normal sharks aren't good enough, so she starts genetic experiments on them. The experiments make the sharks larger and smart as dolphins. Plus it makes them more aggressive... Written by Brio

Doctors in an underwater laboratory discover a chemical in the brains of sharks capable of reviving human brain cells. Using gene therapy the doctors create sharks with larger brain masses as a way to speed up the production of the life saving antidote. The result is a breed of Mako that is bigger, stronger, smarter, faster and more fierce then anything man has seen before. The sharks gain the ability to reason and turn on their masters resulting in an all or nothing fight to the finish between man and the ultimate predator. Written by Liked it

A group of research scientists, working in an abandoned off-shore submarine facility, appear to have discovered a neuro-stimulant, extracted from the brains of sharks, that cures Alzheimer's disease. However, unknown to the rest of the researchers the project leaders Dr. Susan McAlester (Saffron Burrows) and Jim Whitlock (Stellan Skarsgård) have illegally used proscribed gene manipulation techniques to enhance the brain size of the sharks to attain their spectacular results. During a severe storm, whilst the researchers are celebrating their success, the newly intelligent sharks attack their captors in a bid to escape. As a result of the storm and the sharks attack strategy, the research facility suffers a catastrophic structural integrity failure and begins to submerge. The situation becomes a deadly race against time as the survivors, led by shark wrangler Carter Blake (Thomas Jane) and Preacher (LL Cool J), try to reach the surface and safety as the deadly intelligent killer-sharks continue to flood the facility and hunt their prey. Everything is at stake for the winners of this deadly game of hunter and hunted! Written by Mark Smith

Trapped Between Infidelity and - [The Deep Blue Sea].